PT-141

Description

PT-141 (Bremelanotide)

PT-141, also known as Bremelanotide, is a research-grade synthetic cyclic peptide derived from the melanocortin peptide family. It is commonly studied for its activity at melanocortin receptors, including MC1R, MC3R, and MC4R, with particular interest in central nervous system signaling, sexual arousal pathways, motivation, and autonomic regulation.

Unlike compounds that act primarily through peripheral vascular mechanisms, PT-141 is investigated for its central activity within hypothalamic and neuroendocrine pathways, making it a valuable research tool for studying melanocortin receptor activation and downstream behavioral signaling.

Melanocortin Receptor Research

PT-141 is studied for its interaction with melanocortin receptors involved in neurological, behavioral, and physiological signaling.

Research models have explored its role in:

• MC3R and MC4R pathway activation
• Hypothalamic signaling
• Dopaminergic and serotonergic pathway modulation
• Arousal and reward-circuit research
• cAMP-related signaling activity
• Melanocortin receptor occupancy studies

MC1R activity has also been examined in relation to pigmentation biology and inflammatory pathway research, providing additional areas of scientific interest beyond central nervous system models.

Central Nervous System Applications

PT-141 has been evaluated in preclinical models involving hypothalamic nuclei, including regions associated with autonomic function, behavioral response, and neuroendocrine regulation.

Areas of ongoing investigation include:

• Sexual behavior research
• Motivation and reward signaling
• Oxytocin and dopamine pathway interaction
• MC4R-dependent response studies
• Neuroendocrine communication
• Central melanocortin pathway mapping

Research using receptor-specific models has helped clarify which observed effects are related to MC4R activity versus broader melanocortin receptor engagement.

Autonomic & Cardiovascular Research

PT-141 is also studied in autonomic pharmacology due to its observed influence on physiological parameters such as blood pressure, heart rate, and nausea-associated signaling pathways.

Current research interest includes:

• Cardiovascular response models
• Autonomic nervous system signaling
• Area postrema receptor activity
• Emetic pathway research
• Melanocortin-related hemodynamic studies

Purity & Quality

PT-141 is supplied as a lyophilized powder intended for laboratory reconstitution. This compound is verified at ≥99% purity by HPLC and third-party tested for identity and sterility.

Disclaimer

For laboratory research use only.
Not intended for human consumption, therapeutic use, disease prevention, diagnosis, or medical application.

Research Information

For additional scientific information regarding this compound, please refer to our complete research guide.