SS-31

Description

SS-31 (Elamipretide)

SS-31, also known as Elamipretide, is a research-grade mitochondria-targeting tetrapeptide studied for its potential role in supporting mitochondrial structure, cellular energy production, and oxidative stress response. This compound is commonly investigated in models involving mitochondrial dysfunction across cardiac, renal, neurological, and musculoskeletal research.

SS-31 is studied for its interaction with cardiolipin, a key phospholipid located within the inner mitochondrial membrane. By targeting this area, researchers use SS-31 to examine mitochondrial stability, bioenergetic efficiency, and cellular resilience under metabolic or oxidative stress conditions.

Mitochondrial Function & Bioenergetic Research

SS-31 is frequently evaluated in studies focused on mitochondrial performance and energy production. Research models have explored its potential influence on:

• Mitochondrial reactive oxygen species regulation
• Cardiolipin protection
• Cristae structure stabilization
• Electron transport chain efficiency
• ATP production
• Reduced electron leakage

In aging and metabolically stressed tissue models, SS-31 has been investigated for its ability to support mitochondrial sensitivity to ADP and improve functional capacity in skeletal muscle, heart, and kidney research settings.

Oxidative Stress & Cellular Protection

SS-31 is also studied for its role in oxidative stress reduction and cellular protection pathways. Areas of ongoing investigation include:

• Mitochondrial permeability transition pore activity
• Cytochrome c release
• Apoptosis and necrosis signaling
• Ischemia-reperfusion injury models
• Neurodegeneration-related research
• Oxidative protein modification

Inflammatory & Metabolic Research

Additional studies have examined SS-31 in relation to inflammatory signaling, redox balance, autophagy markers, and metabolic stress. This has made it a compound of interest in research involving type 2 diabetes models, mitochondrial aging, and chronic oxidative stress conditions.

Disclaimer

For laboratory research use only.
Not intended for human consumption, therapeutic use, or medical application.

Research Information

For additional scientific information regarding this compound, please refer to our complete research guide.